5166-67-6
- Product Name：Ethyl 1-methylpiperidine-3-carboxylate
- Molecular Formula：C9H17NO2
- Purity：99%
- Molecular Weight：171.239
Product Details:
CasNo： 5166-67-6
Molecular Formula： C9H17NO2
Appearance： Clear colorless to pale yellow liquid
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Factory Supply High Purity 99% Ethyl 1-methylpiperidine-3-carboxylate 5166-67-6 Safe Delivery
- Molecular Formula:C9H17NO2
- Molecular Weight:171.239
- Appearance/Colour:Clear colorless to pale yellow liquid
- Vapor Pressure:0.186mmHg at 25°C
- Refractive Index:n20/D 1.451(lit.)
- Boiling Point:211.1 °C at 760 mmHg
- PKA:8.56±0.10(Predicted)
- Flash Point:68.3 °C
- PSA：29.54000
- Density:0.997 g/cm3
- LogP:0.82920
Ethyl 1-methylnipecotate(Cas 5166-67-6) Usage
|
Chemical Properties |
Clear colorless to pale yellow liquid |
|
Uses |
Reactant for: N-demethylation of tertiary amines Reverse cope elimination reactions Regioselective oxidation Synthesis of chelating agents Sequential Michael-Michael-Dieckmann cyclizations |
|
General Description |
Enantiomeric discrimination has been investigated in 1H and 13C NMR spectra of ethyl 1-methyl-3-piperidinecarboxylate in the presence of (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. |
InChI:InChI=1/C9H17NO2/c1-3-12-9(11)8-5-4-6-10(2)7-8/h8H,3-7H2,1-2H3/p+1/t8-/m0/s1
5166-67-6 Relevant articles
The elimination kinetics and mechanisms of ethyl piperidine-3-carboxylate, ethyl 1-methylpiperidine-3-carboxylate, and ethyl 3-(piperidin-1-yl)propionate in the gas phase
Angiebelk Monsalve, Felix Rosas, María Tosta, Armando Herize, Rosa M. Domínguez, Doris Brusco, Gabriel Chuchani
International Journal of Chemical Kinetics, Volume38, Issue2 February 2006 Pages 106-114
The rate coefficients are given by the following Arrhenius expressions: ethyl 3-(piperidin-1-yl) propionate, log k1(s−1) = (12.79 ± 0.16) − (199.7 ± 2.0) kJ mol−1 (2.303 RT)−1; ethyl 1-methylpiperidine-3-carboxylate, log k1(s−1) = (13.07 ± 0.12)–(212.8 ± 1.6) kJ mol−1 (2.303 RT)−1; ethyl piperidine-3-carboxylate, log k1(s−1) = (13.12 ± 0.13) − (210.4 ± 1.7) kJ mol−1 (2.303 RT)−1; and 3-piperidine carboxylic acid, log k1(s−1) = (14.24 ± 0.17) − (234.4 ± 2.2) kJ mol−1 (2.303 RT)−1.
REDUCTIVE ALKYLATION OF AMINES WITH ORTHOCARBOXYLIC ACID ESTERS
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Page/Page column 9; 14, (2017/12/27)
The present invention relates to a proce...
COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING
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Page/Page column 126, (2011/08/03)
Disclosed are muscarinic agonist compoun...
5166-67-6 Process route
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- 50-00-0,30525-89-4,61233-19-0
formaldehyd
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- 71962-74-8
Ethyl nipecotate
-
- 5166-67-6
ethyl 1-methylpiperidine-3-carboxylate
| Conditions | Yield |
|---|---|
|
With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; at 20 ℃;
|
42.09 g |
|
formaldehyd; Ethyl nipecotate; With hydrogen; acetic acid; palladium 10% on activated carbon; In water; at 20 ℃; for 17h; under 760.051 Torr;
With potassium carbonate; In water; toluene; pH=9;
|
-
- 122-51-0
orthoformic acid triethyl ester
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- 71962-74-8
Ethyl nipecotate
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- 5166-67-6
ethyl 1-methylpiperidine-3-carboxylate
| Conditions | Yield |
|---|---|
|
With platinum on carbon; hydrogen; toluene-4-sulfonic acid; at 120 ℃; for 0.2h; under 30003 Torr; Reagent/catalyst; Inert atmosphere; Autoclave;
|
90% |
|
orthoformic acid triethyl ester; Ethyl nipecotate; With platinum on carbon; hydrogen; toluene-4-sulfonic acid; In ethanol; at 25 ℃; for 24h; under 30003 Torr; Autoclave;
With hydrogenchloride; In ethanol; water;
|
90% |
5166-67-6 Upstream products
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614-18-6
3-pyridinecarboxylic acid ethyl ester
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108320-80-5
3-ethoxycarbonyl-1-methyl-pyridinium; bromide
-
56338-90-0
3-ethoxycarbonyl-1-methylpyridinium chloride
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71962-74-8
Ethyl nipecotate
5166-67-6 Downstream products
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114193-37-2
N-methyl-N-(3-phenyl-5-isoxazolyl)-1-methylnipecotamide
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470700-27-7
ethyl 1-methyl-3-(phenylsulfanyl)piperidine-3-carboxylate
-
4842-86-8
ethyl piperidine-3-carboxylate hydrochloride
-
626-67-5
N-methylcyclohexylamine
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