What is the Indapamide?

Indapamide is Crystalline solid, while it's Molecular Formula is C16H16ClN3O3S. Crystalline solid Used as an antihypertensive. Diuretic.

What is the CAS number for Indapamide?

The CAS number of Indapamide is 26807-65-8.

What is Indapamide (26807-65-8) used for?

Indapamide (Item No. 21308) is an analytical reference standard that is categorized as a sulfonamide diuretic that blocks delayed-rectifier potassium currents. Formulations containing indapamide are used to treat hypertension, but it is abused by athletes to reduce body weight rapidly or mask the presence of other athletic-enhancing substances. Indapamide can be detected in urine. This product is intended for research and forensic applications.InChI:InChI=1/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)

What is the Indapamide?

Indapamide is Crystalline solid, while it's Molecular Formula is C16H16ClN3O3S. Crystalline solid Used as an antihypertensive. Diuretic.

What is the CAS number for Indapamide?

The CAS number of Indapamide is 26807-65-8.

What is Indapamide (26807-65-8) used for?

Indapamide (Item No. 21308) is an analytical reference standard that is categorized as a sulfonamide diuretic that blocks delayed-rectifier potassium currents. Formulations containing indapamide are used to treat hypertension, but it is abused by athletes to reduce body weight rapidly or mask the presence of other athletic-enhancing substances. Indapamide can be detected in urine. This product is intended for research and forensic applications.InChI:InChI=1/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)

Product Class

26807-65-8

Product Name：Indapamide
Molecular Formula：C₁₆H₁₆ClN₃O₃S
Purity：99%
Molecular Weight：365.84

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Product Details:

CasNo： 26807-65-8

Molecular Formula： C₁₆H₁₆ClN₃O₃S

Appearance： Crystalline solid

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Molecular Formula:C16H16ClN3O3S
Molecular Weight:365.84
Appearance/Colour:Crystalline solid
Melting Point:160-162 °C
Refractive Index:1.693
Boiling Point:110.4°C (rough estimate)
PKA:pKa (25°) 8.8 ± 0.2
PSA：100.88000
Density:1.51 g/cm³
LogP:4.32040

Indapamide(Cas 26807-65-8) Usage

Description	Indapamide is a type of medicine classified as a diuretic, commonly known as a "water pill." It works by increasing urine production, helping to eliminate excess fluid from the body. Indapamide is primarily used to treat high blood pressure (hypertension) and salt and fluid retention (edema) associated with congestive heart failure.
Uses	High Blood Pressure (Hypertension): Indapamide is prescribed alone or in combination with other medications to manage high blood pressure. By reducing blood volume, it helps decrease the workload on the heart and arteries, thus lowering blood pressure. Congestive Heart Failure: It is used to treat salt and fluid retention caused by congestive heart failure. By promoting diuresis, indapamide helps reduce fluid buildup in the body, relieving symptoms such as swelling and shortness of breath.
Category toxic	Substances
Toxicity grading	Medium toxicity
Acute toxicity	Oral-rat LD50:> 3000 mg/kg; Oral-mouse LD50:> 3000 mg/kg.
Brand name	Lozol (Sanofi Aventis).

InChI:InChI=1/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)

26807-65-8 Relevant articles

One-pot Synthesis of the Indole Derivative 4-Chloro-3-sulphamoyl-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide (Indapamide)

Ziobro, Barbara,Sienkiewicz, Barbara,Kowalski, Piotr

, p. 95 - 97 (2004)

New methods for the synthesis the indole...

Pharmacokinetics and clinical pharmacology of indapamide

Frank S Caruso Ph.D., Romana R Szabadi Ph.D., Robert A Vukovich Ph.D.

American Heart Journal Volume 106, Issue 1, Part 2, July 1983, Pages 212-220

Disappearance of indapamide from the blood is biphasic, with a terminal half-life of approximately 16 hours. Renal clearance represents less than 10% of the total systemic clearance of the parent drug, showing the dominant role of hepatic clearance. Studies of 14C-labeled indapamide in humans demonstrate that 70% of the radioactivity is excreted in urine and 23% in feces.