What is the (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one?

(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one is , while it's Molecular Formula is C 30 H 30 F 2 N 6 O 3 . Sotorasib (AMG510) is the first KRAS (G12C) inhibitor to enter clinical development. Having shown antitumor activity in clinical trials, AMG 510 represents a potentially transformative therapy.

What is the CAS number for (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one?

The CAS number of (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one is 2296729-00-3.

What is (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one (2296729-00-3) used for?

Sotorasib (AMG510) is a chiral compound and a potent KRAS G12C covalent inhibitor with potential antitumor activity.

What is the (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one?

(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one is , while it's Molecular Formula is C 30 H 30 F 2 N 6 O 3 . Sotorasib (AMG510) is the first KRAS (G12C) inhibitor to enter clinical development. Having shown antitumor activity in clinical trials, AMG 510 represents a potentially transformative therapy.

What is the CAS number for (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one?

The CAS number of (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one is 2296729-00-3.

What is (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one (2296729-00-3) used for?

Sotorasib (AMG510) is a chiral compound and a potent KRAS G12C covalent inhibitor with potential antitumor activity.

Product Class

2296729-00-3

Product Name：Sotorasib
Molecular Formula：C₃₀H₃₀F₂N₆O₃
Purity：99%
Molecular Weight：560.603

Inquiry

Product Details:

CasNo： 2296729-00-3

Molecular Formula： C₃₀H₃₀F₂N₆O₃

Buy High Quality Sotorasib,Export 2296729-00-3 Best Price

Molecular Formula:C₃₀H₃₀F₂N₆O₃
Molecular Weight:560.603
Boiling Point:730.5±70.0 °C(Predicted)
Density:1.36±0.1 g/cm3(Predicted)

Sotorasib (Cas 2296729-00-3) Usage

Description

Sotorasib, sold under the brand names Lumakras and Lumykras, is an anti-cancer medication used to treat non-small-cell lung cancer (NSCLC). Specifically designed for adults who have undergone at least one prior treatment and have NSCLC that has either spread to other parts of the body or is unresectable, Sotorasib operates as a KRAS inhibitor. This means it targets the abnormal protein G12C mutation in the K-Ras gene (KRAS), which is implicated in various forms of cancer.

Uses

As a KRAS inhibitor, Sotorasib works by blocking the action of the mutated KRAS protein, disrupting its signaling pathway and thereby impeding the multiplication of cancer cells. Commonly known side effects of Sotorasib therapy, as noted by NCBI Bookshelf, include serum aminotransferase elevations and severe liver injury. Sotorasib's availability under the brand names Lumakras and Lumykras underscores its role in addressing refractory cases of non-small cell lung cancer, particularly those with the KRAS G12C mutation, which accounts for up to 13% of such cases. This small molecule inhibitor holds promise as an effective treatment strategy for individuals with advanced NSCLC who have exhausted other therapeutic options.

2296729-00-3 Relevant articles

Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial

Adrianus Johannes de Langen, MD PhD Assist Prof Melissa L Johnson, MD Prof Julien Mazieres, MD PhD Prof Anne-Marie C Dingemans, MD PhD Giannis Mountzios, MD PhD Prof Miklos Pless, MD

, The Lancet, 2023

We randomly assigned (1:1) patients to oral sotorasib (960 mg once daily) or intravenous docetaxel (75 mg/m2 once every 3 weeks) in an open-label manner using interactive response technology. Randomisation was stratified by number of previous lines of therapy in advanced disease (1 vs 2 vs >2), ethnicity (Asian vs non-Asian), and history of CNS metastases (present or absent).

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Lanman, Brian A.,Allen, Jennifer R.,Allen, John G.,Amegadzie, Albert K.,Ashton, Kate S.,Booker, Shon K.,Chen, Jian Jeffrey,Chen, Ning,Frohn, Michael J.,Goodman, Guy,Kopecky, David J.,Liu, Longbin,Lopez, Patricia,Low, Jonathan D.,Ma, Vu,Minatti, Ana E.,Nguyen, Thomas T.,Nishimura, Nobuko,Pickrell, Alexander J.,Reed, Anthony B.,Shin, Youngsook,Siegmund, Aaron C.,Tamayo, Nuria A.,Tegley, Christopher M.,Walton, Mary C.,Wang, Hui-Ling,Wurz, Ryan P.,Xue, May,Yang, Kevin C.,Achanta, Pragathi,Bartberger, Michael D.,Canon, Jude,Hollis, L. Steven,McCarter, John D.,Mohr, Christopher,Rex, Karen,Saiki, Anne Y.,San Miguel, Tisha,Volak, Laurie P.,Wang, Kevin H.,Whittington, Douglas A.,Zech, Stephan G.,Lipford, J. Russell,Cee, Victor J.

, p. 52 - 65 (2020/01/09)

KRASG12C has emerged as a promising targ...

2296729-00-3 Process route

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 2252403-56-6,2296729-00-3
(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 1.2: 0.5 h / 0 °C 2.1: tetrahydrofuran; dichloromethane / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C / Cooling with ice 4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 80 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C / Cooling with ice 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / water; 1,4-dioxane / 1 h / 90 °C / Inert atmosphere 7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 7.2: 0.17 h / 0 °C With* dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
Multi-step reaction with 8 steps 1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 16 h / 20 °C 1.2: 0.5 h / 0 °C 2.1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 1 h / 75 °C / Cooling with ice 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C / Cooling with ice 4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 80 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C / Cooling with ice 5.2: 0.08 h 6.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dichloromethane; 1,4-dioxane / 1 h / 90 °C / Inert atmosphere 7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C 8.2: Chiralpak IC / 76507.7 Torr / Supercritical conditions With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
Multi-step reaction with 6 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 15 - 20 °C / Large scale 2.1: dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 3.5 h / 0 - 45 °C / Large scale 4.2: 0.25 h / 25 °C / Large scale 5.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 6.2: 0.17 h / 0 °C With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
Multi-step reaction with 7 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 15 - 20 °C / Large scale 2.1: dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / 80 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C 6.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 7.2: 0.17 h / 0 °C With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
Multi-step reaction with 7 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 15 - 20 °C / Large scale 2.1: dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 3.5 h / 0 - 45 °C / Large scale 4.2: 0.25 h / 25 °C / Large scale 5.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 6.1: trifluoroacetic acid / dichloromethane / 20 °C / Large scale 6.2: Large scale 7.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 - 30 °C With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene;
Multi-step reaction with 8 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 15 - 20 °C / Large scale 2.1: dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / 80 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C 6.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 7.1: trifluoroacetic acid / dichloromethane / 20 °C / Large scale 7.2: Large scale 8.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 - 30 °C With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetonitrile;
Multi-step reaction with 6 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 2.1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 3 h / 0 - 45 °C / Large scale 4.2: 0.25 h / 25 °C / Large scale 5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 6.2: 0.17 h / 0 °C With* dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
Multi-step reaction with 7 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 2.1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 3 h / 0 - 45 °C / Large scale 4.2: 0.25 h / 25 °C / Large scale 5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 6.1: trifluoroacetic acid; potassium carbonate / dichloromethane; water; methanol / 14 h / 20 °C 7.1: 1-methyl-pyrrolidin-2-one / 2 h / 30 °C With* dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; toluene;
Multi-step reaction with 7 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 2.1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / 80 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 7.2: 0.17 h / 0 °C With* dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
Multi-step reaction with 8 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 2.1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 1 h / 75 °C 2.2: 1 h / 0 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / 80 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 7.1: trifluoroacetic acid; potassium carbonate / dichloromethane; water; methanol / 14 h / 20 °C 8.1: 1-methyl-pyrrolidin-2-one / 2 h / 30 °C With* dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; acetonitrile;
Multi-step reaction with 11 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 15 - 20 °C / Large scale 1.2: 1.5 h / 0 °C / Large scale 2.1: dichloromethane / 4.25 h / 25 - 40 °C / Large scale 3.1: dichloromethane / 1 h / 0 - 23 °C / Large scale 4.1: sodium t-butanolate / 2-methyltetrahydrofuran / 3 h / 5 - 23 °C / Large scale 5.1: 2-methyltetrahydrofuran / 0.5 h / 75 °C / Inert atmosphere; Large scale 6.1: disodium hydrogenphosphate / water; tert-butyl methyl ether / 3 h / Large scale 7.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 7 h / 30 °C / Large scale 8.1: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene; Isopropyl acetate / 1 h / 20 °C / Large scale 9.1: potassium acetate; dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll) / water; 2-methyltetrahydrofuran / 75 °C / Large scale 10.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Large scale 11.1: trifluoroacetic acid / 1-methyl-pyrrolidin-2-one / 1.5 h / 0 - 10 °C / Inert atmosphere; Large scale With disodium hydrogenphosphate; oxalyl dichloride; dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); potassium acetate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; In 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; tert-butyl methyl ether; Isopropyl acetate; water; toluene;
Multi-step reaction with 8 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 1.2: 0.5 h / 0 °C 2.1: dichloromethane; tetrahydrofuran / 1 h / 75 °C / Cooling with ice 3.1: oxalyl dichloride / tetrahydrofuran / 1 h / 0 °C 4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / 20 °C / Cooling with ice 5.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 80 °C 6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C / Cooling with ice 7.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere 8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 8.2: 0.17 h / 0 °C With* dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;

: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methylpiperazin-1-yl]-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]pyrido[2,3-d]pyrimidin-2(1H)-one

: 814-68-6,25189-84-8
acryloyl chloride

: 2252403-56-6,2296729-00-3
(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one