What is the Cancidas?

Cancidas is white powder, while it's Molecular Formula is 2C 2 H 4 O 2 *C 52 H 88 N 10 O 15 . white powder Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

What is the CAS number for Cancidas?

The CAS number of Cancidas is 179463-17-3.

What is Cancidas (179463-17-3) used for?

Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall. It is effective against disseminated or invasive aspergillosis and candidiasis in mice. Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml. It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.InChI:InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

What is the Cancidas?

Cancidas is white powder, while it's Molecular Formula is 2C 2 H 4 O 2 *C 52 H 88 N 10 O 15 . white powder Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

What is the CAS number for Cancidas?

The CAS number of Cancidas is 179463-17-3.

What is Cancidas (179463-17-3) used for?

Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall. It is effective against disseminated or invasive aspergillosis and candidiasis in mice. Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml. It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.InChI:InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

Product Class

179463-17-3

Product Name：Caspofungin Acetate
Molecular Formula：C₅₂H₈₈N₁₀O₁₅^.2(C₂H₄O₂)
Purity：99%
Molecular Weight：1213.43

Inquiry

Product Details:

CasNo： 179463-17-3

Molecular Formula： C₅₂H₈₈N₁₀O₁₅^.2(C₂H₄O₂)

Appearance： white powder

Chinese Factory Supply High Purity Caspofungin Acetate 179463-17-3 Safe Delivery

Molecular Formula:2C₂H₄O₂*C₅₂H₈₈N₁₀O₁₅
Molecular Weight:1213.43
Appearance/Colour:white powder
Vapor Pressure:0mmHg at 25°C
Boiling Point:1501.4 °C at 760 mmHg
Flash Point:861.8 °C
PSA：412.03000
LogP:0.06150

Caspofungin Acetate (Cas 179463-17-3) Usage

Description	Caspofungin Acetate is a pioneering antifungal agent belonging to the echinocandin class. It is used intravenously for the treatment of invasive aspergillosis in patients who are refractory to or intolerant of other antifungal therapies. Caspofungin is a stable, water-soluble derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. It stands out by inhibiting the synthesis of 1,3-beta-D-glucans present exclusively in the fungal cell wall, leading to specific lysis of pathogenic cells. This fungicidal characteristic is unusual among antifungal agents.
Chemical Properties	White Solid
Originator	Merck & Co (US)
Uses	With a focus on fungus-specific targets, Caspofungin demonstrates efficacy against various Candida species, including those resistant to azoles and amphotericin B. It also acts against Aspergillus, a significant pathogen resistant to fluconazole. However, Cryptococcus is not susceptible to Caspofungin. Unlike azoles, Caspofungin does not inhibit cytochrome P450. The drug, given intravenously with a loading dose of 70 mg followed by 50 mg daily, has proven effective in treating invasive aspergillosis refractory to prior antifungal therapy. Caspofungin has a human half-life of around 10 hours, and its side effects are generally mild, including fever, thrombophlebitis, headache, nausea, rash, and flushing. As an echinocandin, it plays a crucial role in inhibiting β (1,3)-D-glucan synthesis, an integral component of the fungal cell wall, making it a valuable antifungal drug for the treatment of invasive fungal infections.
Definition	ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.
Brand name	Cancidas (Merck).

InChI:InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

179463-17-3 Relevant articles

CASPOFUNGIN ANALOG AND APPLICATIONS THEREOF

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, (2017/02/28)

Disclosed are a caspofungin analog and a...

PROCESS FOR PREPARATION OF CASPOFUNGIN ACETATE AND INTERMEDIATES

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Page/Page column, (2014/02/15)

The present invention discloses a proces...

Safety and tolerability of caspofungin acetate in the treatment of fungal infections

C.A. Sable, B-Y T. Nguyen, J.A. Chodakewitz, M.J. DiNubile

Transplant Infectious Disease, Volume4, Issue1 March 2002 Pages 25-30

The safety and tolerability of caspofungin have been examined in 623 persons, including 295 patients who received ≥ 50 mg/day for at least one week in clinical studies.

179463-17-3 Process route

: 64-19-7,77671-22-8
acetic acid

: 107-15-3,85404-18-8
ethylenediamine

: L-731,373*HCl

: 179463-17-3
caspofungin acetate

Conditions

Conditions	Yield
L-731,373HCl; With* 1H-tetrazole; trifluorormethanesulfonic acid; phenylboronic acid; In tetrahydrofuran; acetonitrile; at -10 ℃; ethylenediamine; In tetrahydrofuran; methanol; acetonitrile; at 20 - 30 ℃; acetic acid; In tetrahydrofuran; methanol; water; acetonitrile; pH=3.8 - 5.2;	32%

: C₅₃H₈₆N₈O₁₇S

: 64-19-7,77671-22-8
acetic acid

: 107-15-3,85404-18-8
ethylenediamine

: 179463-17-3
caspofungin diacetate