152520-56-4
- Product Name:Nebivolol hcl
- Molecular Formula:C22H25F2NO4.HCl
- Purity:99%
- Molecular Weight:441.90
Product Details:
CasNo: 152520-56-4
Molecular Formula: C22H25F2NO4.HCl
Appearance: White to off-white powder
Buy Quality Nebivolol hcl,Wholesale 152520-56-4 In Bulk Supply
- Molecular Formula:C22H25F2NO4.HCl
- Molecular Weight:441.90
- Appearance/Colour:White to off-white powder
- Vapor Pressure:2.88E-15mmHg at 25°C
- Melting Point:220-222 °C
- Boiling Point:600.5 °C at 760 mmHg
- Flash Point:316.9 °C
- PSA:70.95000
- LogP:3.55650
Nebivolol hydrochloride(Cas 152520-56-4) Usage
Chemical Properties |
White to Off-White Powder |
Description |
Nebivolol hydrochloride is a highly selective antagonist of the β1-adrenoceptor, primarily used in the treatment of hypertension. It acts as a β1-adrenergic receptor blocker, with a high affinity for this receptor subtype. Nebivolol hydrochloride has been specifically formulated for patients who may have difficulty swallowing tablets. |
Uses |
Nebivolol is utilized alone or in combination with other medications to manage high blood pressure (hypertension). Hypertension increases the workload on the heart and arteries, potentially leading to impaired function over time. By blocking the β1-adrenergic receptors, nebivolol helps reduce blood pressure and alleviate the strain on the cardiovascular system. |
InChI:InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H
152520-56-4 Relevant articles
Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations
A. LAKSHMANA RAO* , K.R. RAJESWARI and G.G. SANKAR
E-Journal of Chemistry, 2010
A simple, sensitive, highly accurate spectrophotometric method in UV region has been developed for the determination of nebivolol hydrochloride in bulk and pharmaceutical formulations. Nebivolol hydrochloride is an antihypertensive drug, which shows maximum absorbance at 281 nm with apparent molar absorptivity of 5.37208 x 103 mol-1 cm-1. Beer’s law was obeyed in the concentration range of 4-60 µg/mL. The slope, intercept and correlation coefficient were also calculated.
Development and Validation for the Simultaneous Quantification of Nebivolol Hydrochloride and Hydrochlorothiazide by UV Spectroscopy, RP-HPLC and HPTLC in Tablets
B. Dhandapani ,1N. Thirumoorthy,2and D. Jose Prakash3
Journal of Chemistry, 2010, Volume 7
Simultaneous quantification of nebivolol hydrochloride (NEB-H) and hydrochlorothiazide (HCT) in tablets by UV spectroscopy, RP-HPLC and HPTLC methods were developed. In UV spectrophotometric determination NEB-H and HCT was quantified by simultaneous equation method and absorbance ratio method. In simultaneous equation method absorbance measurements at 282.5 nm (λmax NEB-H) and 271.5 nm (λmax HCT),
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