What is the Moxifloxacin hydrochloride?

Moxifloxacin hydrochloride is 99%, while it's Molecular Formula is C21H24FN3O4.ClH. 99% An antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV

What is the CAS number for Moxifloxacin hydrochloride?

The CAS number of Moxifloxacin hydrochloride is 186826-86-8.

What is Moxifloxacin hydrochloride (186826-86-8) used for?

Moxifioxacin hydrochlodde is one of the two new fluoroquinolonecarboxylicacid antibiotics introduced in 1999 for the treatment ofrespiratory tract infections such as community-acquired pneumonia, acuteexacerbations of bronchitis or acute sinusitis. Moxifloxacin can be synthesizedthrough a 12 step sequence from the classical 4-quinolone-3-carboxylic acidtemplate. Some advantages of Moxifloxacin over Ciprofloxacin, another ofBayer's launched quinolones, have been shown, i.e. an enhanced activityagainst Gram-positive bacteria (Streptococcus pneumoniae, Clostndiumpneumoniae), a favorable pharmacokinetic profile (good tissue penetration andplasma concentrations above MICs) and a lack of phototoxicity (UVAirradiation).InChI:InChI=1/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H

Product Class

186826-86-8

Product Name：Moxifloxacine Hcl
Molecular Formula：C₂₁H₂₄FN₃O₄.ClH
Purity：99%
Molecular Weight：437.899

Inquiry

Product Details:

CasNo： 186826-86-8

Molecular Formula： C₂₁H₂₄FN₃O₄.ClH

Appearance： 99%

Quality Factory Supply 186826-86-8 Reasonable Price, Sale Moxifloxacine Hcl

Molecular Formula:C21H24FN3O4.ClH
Molecular Weight:437.899
Appearance/Colour:99%
Vapor Pressure:4.56E-17mmHg at 25°C
Melting Point:Slightly yellow to yellow crystalline powder, mp 324-325°
Boiling Point:636.4 °C at 760 mmHg
Flash Point:338.7 °C
PSA：83.80000
LogP:3.56630

Moxifloxacin hydrochloride(Cas 186826-86-8) Usage

Description	Moxifloxacin Hydrochloride is the hydrochloride salt of moxifloxacin, a fluoroquinolone antibiotic. Fluoroquinolones are a class of antibiotics that target bacterial DNA gyrase (topoisomerase II) and topoisomerase IV enzymes, thereby inhibiting DNA replication, repair, and ultimately leading to bacterial cell death.
Chemical Properties	Light yellow to yellow crystalline powder
Originator	Bayer (Germany)
Uses	Treatment of Bacterial Infections: Moxifloxacin Hydrochloride is used to treat bacterial infections affecting various parts of the body, including respiratory tract infections, skin and soft tissue infections, intra-abdominal infections, and urinary tract infections. It is effective against a wide range of gram-positive and gram-negative bacteria. Treatment and Prevention of Plague: Moxifloxacin Hydrochloride is also indicated for the treatment and prevention of plague, including pneumonic (lung) and septicemic (bloodstream) forms of the disease. Plague is a severe bacterial infection caused by Yersinia pestis, and moxifloxacin is one of the antibiotics recommended for its treatment. Mechanism of Action: Moxifloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for DNA replication and repair in bacteria. By interfering with these processes, moxifloxacin disrupts bacterial growth and ultimately leads to bacterial cell death.

InChI:InChI=1/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H

186826-86-8 Relevant articles

Preparation method of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative

-

, (2021/10/27)

The invention belongs to the field of ph...

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

Gasser M. Khairy 1,ORCID,Zaitona A. Abd El-Naby 2,Alaa M. A. Elgindy 2,Axel Duerkop 3,ORCID andEman A. Abdel Hameed 4

, Chemosensors 2022, 10(10), 378;

A new probe based on the complex of 1,2 dihydro-2-oxoquinoloine-4-carboxylic acid (DOCA) as a ligand with Europium (III) ion was developed for the quantitation of Moxifloxacin HCl (Moxi.HCl) in pharmaceuticals and human plasma using a luminescence method. The metal to ligand ratio of the complex is 1:2 as determined by a Job plot. The determination of Moxi.HCl is based on static quenching of the luminescence of the probe upon coordination of Moxi.HCl.

Validated spectrophotometric methods for the estimation of moxifloxacin in bulk and pharmaceutical formulations

Sanjay K. Motwani, Shruti Chopra 1, Farhan J. Ahmad 1, Roop K. Khar 1

, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Volume 68, Issue 2, October 2007, Pages 250-256

Moxifloxacin is a fourth generation 8-methoxy fluoroquinolone derivative [1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-{(4aS,7aS–octa-hydro-6H-pyrrolol (3,4b) pyridin-6-yl)}-4-oxo-3-quinoline carboxylic acid, monohydrochloride] with extended-spectrum and improved activity against Gram-positive bacteria (including staphylococci, streptococci, enterococci), anaerobes and atypical bacteria

186826-86-8 Process route

: (4aS-cis)-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate

: 186826-86-8,1246654-75-0,1346603-25-5
moxifloxacin hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; In methanol; water; at 0 - 8 ℃; for 0.333333h; Temperature;	96.2%
With hydrogenchloride; In water; at 0 ℃; for 4h; pH=< 1;	96.5%
With hydrogenchloride; In methanol; at -5 - 20 ℃; for 2h; pH=1; Temperature;	93.1%
With sodium hydroxide; In acetone; for 1h; Large scale;	89.8%
With sodium hydroxide; at 80 ℃; for 2.5h;	84.75%
With hydrogenchloride; In water; at 10 - 15 ℃; for 6h; pH=1.0 - 2.0;	118 g
With hydrogenchloride; In ethanol; water; at 25 ℃; for 1h; pH=1; Temperature;	48 g

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0,158060-81-2,169533-56-6
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 186826-86-8,1246654-75-0,1346603-25-5
moxifloxacin hydrochloride