What is the (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone?

(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone is , while it's Molecular Formula is C 23 H 23 ClN 6 O 2 . [(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone,

What is the CAS number for (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone?

The CAS number of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone is 1505484-82-1.

What is the (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone?

(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone is , while it's Molecular Formula is C 23 H 23 ClN 6 O 2 . [(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone,

What is the CAS number for (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone?

The CAS number of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone is 1505484-82-1.

Product Class

1505484-82-1

Product Name：Nemorexant
Molecular Formula：C₂₃H₂₃ClN₆O₂
Purity：99%
Molecular Weight：450.928

Inquiry

Product Details:

CasNo： 1505484-82-1

Molecular Formula： C₂₃H₂₃ClN₆O₂

Factory Supply High Purity Nemorexant 1505484-82-1,Factory Sells 1505484-82-1 Best Price

Molecular Formula:C₂₃H₂₃ClN₆O₂
Molecular Weight:450.928
Boiling Point:747.6±70.0 °C(Predicted)
Density:1.42±0.1 g/cm3(Predicted)

Nemorexant(Cas 1505484-82-1) Usage

Description	Nemeroxant is a selective dual orexin receptor antagonist (DORA) that is used to treat insomnia. It is also known by the name daridorexant.
Uses	Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning.

1505484-82-1 Relevant articles

CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites

A Treiber，H Aissaoui，S Delahaye，S Glutz，J Grimont，C Müller，S Seeland，V Siefken，C Boss

, ChemMedChem, 2023

With human liver microsomes, daridorexant underwent hydroxylation at the methyl group of the benzimidazole moiety, oxidative O‐demethylation of the anisole to the corresponding phenol, and hydroxylation to a 4‐hydroxy piperidinol derivative.

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

Boss, Christoph,Gatfield, John,Brotschi, Christine,Heidmann, Bibia,Sifferlen, Thierry,von Raumer, Markus,Schmidt, Gunther,Williams, Jodi T.,Treiber, Alexander,Roch, Catherine

, p. 2286 - 2305 (2020)

Since its discovery in 1998, the orexin ...

1505484-82-1 Process route

: 1293284-55-5
5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid

: C₁₃H₁₆ClN₃*ClH

: 1505484-82-1
(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 16h;	63%

: 103336-06-7
N-(tert-butoxycarbonyl)-2-methyl-L-proline

: 1505484-82-1
(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C 1.2: 1 h / 100 °C 2.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C 3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;

Yield

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C

1.2: 1 h / 100 °C

2.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;

1505484-82-1 Upstream products

103336-06-7
N-(tert-butoxycarbonyl)-2-methyl-L-proline
673487-36-0
4-chloro-3-methylbenzene-1,2-diamine
1293284-55-5
5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid
54413-93-3
2-iodo-5-methoxybenzoic acid

Relevant Products

Milvexian
CAS：1802425-99-5
Moxifloxacine Hcl
CAS：186826-86-8
Lacosamide
CAS：175481-36-4