LEE011 is , while it's Molecular Formula is C23H30N8O. LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.

What is the CAS number for LEE011?

The CAS number of LEE011 is 1211441-98-3.

What is LEE011 (1211441-98-3) used for?

LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).

LEE011 is , while it's Molecular Formula is C23H30N8O. LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.

What is the CAS number for LEE011?

The CAS number of LEE011 is 1211441-98-3.

What is LEE011 (1211441-98-3) used for?

LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).

Product Class

1211441-98-3

Product Name：Ribociclib
Molecular Formula：C23H30N8O
Purity：99%
Molecular Weight：434.544

Inquiry

Product Details:

CasNo： 1211441-98-3

Molecular Formula： C23H30N8O

Buy Quality Ribociclib,Export 1211441-98-3 Safe Delivery

Molecular Formula:C23H30N8O
Molecular Weight:434.544
Vapor Pressure:0-0Pa at 20-25℃
Boiling Point:730.8±70.0 °C(Predicted)
PKA:8.67±0.10(Predicted)
PSA：91.21000
Density:1.39±0.1 g/cm3(Predicted)
LogP:3.26320

Ribociclib(Cas 1211441-98-3) Usage

Description	Fezolinetant is a neurokinin 3 (NK3) receptor antagonist, a class of medications that works by altering the nerve response that triggers the thermoregulatory center, thereby reducing vasomotor symptoms such as hot flashes. It is a small-molecule, orally active drug.
Uses	Fezolinetant is used to reduce moderate to severe symptoms of menopause, including hot flashes, sweating, flushing, and chills. It is designed to reduce the frequency and severity of these symptoms by blocking neurokinin B (NKB) binding on the kisspeptin/neurokinin/dynorphin (KNDy) neuron, thus modulating neuronal activity in the hypothalamus, the brain's temperature control center.

1211441-98-3 Relevant articles

Treatment of pre- and postmenopausal Women with HR+/HER2-metastatic Breast Cancer Ribociclib receives high AGO Recommendation Level

SM Rudesheim

, Oncology research and treatment. 2023

The use of ribociclib in the treatment of metastatic breast cancer should be determined on a case-by-case basis, taking into account factors such as disease characteristics, patient preferences, and potential side effects.

PHARMACEUTICAL COMBINATION COMPRISING TNO155 AND RIBOCICLIB

YNP Chen，H Hao，C Liu，M Mohseni

, US2022160707A1

The present invention relates to a pharmaceutical combination comprising TNO155 and ribociclib; pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of conditions in a SHP2 inhibitor combined with CDK4/6 inhibition is beneficial in, for example, the treatment of cancers.

SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF

-

, (2012/05/20)

This invention relates to (1) process of...

1211441-98-3 Process route

: 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1211441-98-3
(7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide)

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogen / palladium 10% on activated carbon / water; methanol / 0.25 h / 19 - 54 °C / 1551.49 - 2327.23 Torr / Inert atmosphere 2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 4-methyl-2-pentanone / 3.25 h / 37 - 103 °C / Inert atmosphere 3.1: hydrogenchloride; water / toluene / 1.08 h / 9 - 28 °C / Inert atmosphere 3.2: Si-thiol functionalized silica gel / 6 h / 30 - 53 °C / pH 2.9 - 3.5 With hydrogenchloride; water; hydrogen; caesium carbonate; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; water; 4-methyl-2-pentanone; toluene;
Multi-step reaction with 3 steps 1.1: hydrogen / methanol / 40 °C 2.1: lithium hexamethyldisilazane / toluene / 0.5 h / Inert atmosphere 2.2: 4 h 3.1: hydrogenchloride / ethyl acetate; water / 10 h With hydrogenchloride; hydrogen; lithium hexamethyldisilazane; In methanol; water; ethyl acetate; toluene;
Multi-step reaction with 3 steps 1: zinc; acetic acid / water / 2 h / 10 - 20 °C 2: sodium hydride; copper(l) iodide / acetonitrile / 1 h / 70 - 80 °C / Inert atmosphere 3: hydrogenchloride / water / 20 - 30 °C With hydrogenchloride; copper(l) iodide; sodium hydride; acetic acid; zinc; In water; acetonitrile;
Multi-step reaction with 4 steps 1: zinc; acetic acid / water / 2 h / 10 - 20 °C 2: sodium hydride; copper(l) iodide / acetonitrile / 1 h / 70 - 80 °C / Inert atmosphere 3: dichloromethane / 5 - 30 °C 4: sodium hydroxide / water / pH 11 - 12 With copper(l) iodide; sodium hydride; acetic acid; sodium hydroxide; zinc; In dichloromethane; water; acetonitrile;

: 79-14-1
glycolic Acid

: 1211441-98-3
(7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide)

: 110-15-6
succinic acid