What is the Risperidone?

Risperidone is crystalline solid, while it's Molecular Formula is C23H27FN4O2. crystalline solid A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist

What is the CAS number for Risperidone?

The CAS number of Risperidone is 106266-06-2.

What is Risperidone (106266-06-2) used for?

Risperidone is a novel antipsychotic introduced for the treatment of acute and chronicschizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonistactivity. While the anti-D2 activity may relate to the antipsychotic potency of neurolepticagents, an antidepressive efficacy of substances with anti-5-HT2 activity has beensuggested. Risperidone, therefore, has therapeutic action on both positive and negativesymptoms of schizophrenia and produces significantly fewer side effects especiallyextrapyramidal symptoms compared with commonly used pure D2 antagonist antipsychotics.It also has potential for management of alcohol withdrawal and cocaine addiction.InChI:InChI=1/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

Product Class

106266-06-2

Product Name：Risperidone
Molecular Formula：C₂₃H₂₇FN₄O₂
Purity：99%
Molecular Weight：410.491

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Product Details:

CasNo： 106266-06-2

Molecular Formula： C₂₃H₂₇FN₄O₂

Appearance： crystalline solid

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Molecular Formula:C23H27FN4O2
Molecular Weight:410.491
Appearance/Colour:crystalline solid
Vapor Pressure:4.14E-13mmHg at 25°C
Melting Point:170 °C
Refractive Index:1.676
Boiling Point:572.4 °C at 760 mmHg
PKA:pKa 8.3 (Uncertain)
Flash Point:300 °C
PSA：64.16000
Density:1.383 g/cm³
LogP:3.52830

Risperidone(Cas 106266-06-2) Usage

Description	Risperidone is a medication used to treat various psychiatric conditions, including schizophrenia, bipolar disorder, and irritability associated with autistic disorder. However, it should not be used to address behavioral problems in older adults with dementia. Risperidone functions by modulating the levels of dopamine and serotonin in the brain, which are neurotransmitters responsible for regulating mood, behaviors, and thoughts.
Uses	Risperidone was developed as a second-generation antipsychotic in response to concerns about agranulocytosis associated with the use of clozapine. Designed by Paul Janssen, risperidone was formulated to antagonize both 5-HT2A and D2 receptors, mirroring the pharmacological mechanism believed to underlie clozapine's antipsychotic effects. Since its introduction in the 1990s, risperidone has gained widespread acceptance due to its improved tolerability profile compared to classical neuroleptics and its broader efficacy spectrum, particularly in addressing negative and depressive symptoms and cognitive disturbances in schizophrenia.
Originator	Janssen (U.S.A.)
Definition	ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Brand name	Risperdal (Janssen).
Clinical Use	Schizophrenia Psychoses Mania Persistent aggression in Alzheimer’s dementia

InChI:InChI=1/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

106266-06-2 Relevant articles

Risperidone A Review of its Pharmacology and Therapeutic Potential in the Treatment of Schizophrenia

Susan Grant & A. Fitton

, Drug Evaluation, Volume 48, pages 253–273, (1994)

Risperidone exhibits central serotonin 5-HT2 and neostriatal dopamine D2 antagonistic activity, but is devoid of anticholinergic activity, in several in vivo animal models. It is also effective in animal behavioural models considered predictive of antipsychotic activity (e.g. suppression of apomorphine- and amphetamine-induced stereotypy and conditioned avoidance behaviour).

Spectroscopic and thermal investigations on the charge transfer interaction between risperidone as a schizophrenia drug with some traditional π-acceptors: Part 2

El-Habeeb, Abeer A.,Al-Saif, Foziah A.,Refat, Moamen S.

, p. 464 - 477 (2013/04/23)

The focus of present investigation was t...

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