Product Class

521284-22-0

Q: What is the CAS number for (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride?

The CAS number of (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride is 521284-22-0.

Product Name：(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride
Molecular Formula：C₁₆H₂₀N₂O^.ClH
Purity：99%
Molecular Weight：292.809

Inquiry

Product Details:

CasNo： 521284-22-0

Molecular Formula： C₁₆H₂₀N₂O^.ClH

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Factory Sells 521284-22-0 Safe Transportation, Quality Manufacturer Supply (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride

Molecular Formula:C16H20N2O^.ClH
Molecular Weight:292.809
Vapor Pressure:0.015Pa at 25℃
PSA：58.28000
Density:1145 at 20℃
LogP:3.90860

(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride(Cas 521284-22-0) Usage

Uses	(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride is a chemical compound used primarily in chemical research and drug synthesis. It is an industry-grade compound available from various suppliers such as Procure-net, AstaTech, and Biosynth. (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride is utilized as a reference standard for pharmaceutical testing, aiding in the development and evaluation of drugs. It plays a crucial role in ensuring the quality and consistency of pharmaceutical products.
Storage	(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride should be stored in a dark place with an inert atmosphere to maintain its stability and integrity over time.
Synthesis	A mixture of (100 g) (R)-2-[2’ -(4-nitrophenyl)ethyl]amino] -1 -phenylethanol monohydroch bride (prepared according to example Ib), methanol (2000 mL) and Raney Nickel (20 g, wet) was stirred under hydrogen pressure (60 psi) for 6 hrs. The reaction solution was filtered, and the filtrate was concentrated in vacuo. The residue was mixed with isopropanol (300 mL) and reaction mixture was heated to 78°C (±2). The mixture was added to toluene (900 mL). The reaction mixture was gradually cooled to 28°C (±2) and stirred at this temperature for 3 hrs. The solid obtained was filtered, washed with toluene and dried under vacuo at 48°C (±2) to obtain (R)-2-[[2-(4-aminophenyl)ethyl]-amino]- I -phenylethanol monohydrochioride.Yield: 78.1 g (86.1%); Purity by HPLC: 99.14 %.

InChI:InChI=1S/C16H20N2O.ClH/c17-15-8-6-13(7-9-15)10-11-18-12-16(19)14-4-2-1-3-5-14;/h1-9,16,18-19H,10-12,17H2;1H/t16-;/m0./s1

521284-22-0 Relevant articles

A new process for the preparation of (R)-2-((4-Aminophenethyl)amino)-1-phenylethanol

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Paragraph 0064-0068, (2021/07/01)

The present invention relates to a proce...

Systematic Investigation into the Formation of Significant Amounts of Unknown Impurity during Scale-up of NaBH4-I2 Mediated Reduction of Nitro-Amide Intermediate of Mirabegron No.

Bangal, Mukund N.,Deshmukh, Dattatray G.,Kalawade, Kaustubh A.,Mathad, Vijayavitthal T.

, p. 286 - 293 (2020/03/10)

After successful development of a manufa...

A PROCESS FOR PREPARATION OF MIRABEGRON AND ALPHA CRYSTALLINE FORM THEREOF

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Page/Page column 33; 34; 35; 36, (2015/04/15)

An improved process for the preparation ...

AN IMPROVED PROCESS FOR THE PREPARATION OF 2-(2-AMINOTHIAZOL-4-YL)-N-[4-(2-[[(2R)-2-HYDROXY-2- PHENYLETHYL]AMINO]-ETHYL)PHENYL]ACETAMIDE

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Page/Page column 19; 20, (2015/11/17)

The present invention relates to an impr...

521284-22-0 Process route

: 29968-78-3
2-(4-nitrophenyl)ethylamine monohydrochloride

: 521284-22-0
(R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: Trimethyl borate; N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / Reflux 2.1: sodium tetrahydroborate / tetrahydrofuran / 25 °C 2.2: 11 h / 0 - 20 °C / Reflux 2.3: 20 - 25 °C 3.1: hydrogen / methanol / 2 h / 20 °C With sodium tetrahydroborate; Trimethyl borate; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetonitrile;

Yield

Multi-step reaction with 3 steps

1.1: Trimethyl borate; N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / Reflux

2.1: sodium tetrahydroborate / tetrahydrofuran / 25 °C

2.2: 11 h / 0 - 20 °C / Reflux

2.3: 20 - 25 °C

3.1: hydrogen / methanol / 2 h / 20 °C

With sodium tetrahydroborate; Trimethyl borate; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetonitrile;

: 611-71-2
(R)-Mandelic Acid

: 521284-22-0
(R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride