78628-80-5
- Product Name：Terbinafine Hcl
- Molecular Formula：C21H26ClN
- Purity：99%
- Molecular Weight：327.897
Product Details:
CasNo： 78628-80-5
Molecular Formula： C21H26ClN
Appearance： Crystalline powder
Chinese Manufacturer Supply Top Purity Terbinafine Hcl 78628-80-5 Fast Shipping
- Molecular Formula:C21H26ClN
- Molecular Weight:327.897
- Appearance/Colour:Crystalline powder
- Vapor Pressure:3.42E-07mmHg at 25°C
- Melting Point:204-208 °C
- Refractive Index:1.586
- Boiling Point:417.9 °C at 760 mmHg
- Flash Point:183.7 °C
- PSA：3.24000
- Density:1.007g/cm3
- LogP:5.67930
Terbinafine Hcl(Cas 78628-80-5) Usage
| Description |
Terbinafine Hydrochloride (TBF-HCl) is an antifungal medication used for the treatment of superficial fungal infections of the skin and nails. It belongs to the group of medicines called antifungals and is specifically indicated for onychomycosis, a fungal infection of the nail plate. |
|
Chemical Properties |
White crystalline powder. Melting point is 204-208 oC. |
| Development and Approval |
Developed by Swiss Novartis in the 1980s. |
|
Originator |
Sandoz (Switzerland) |
|
Uses |
Terbinafine HCl is primarily used to treat onychomycosis, the most common disease of the nail plate caused by fungal infection. Additionally, Terbinafine HCl is used to treat fungal skin infections caused by various fungi species such as Trichophyton, Microsporum, and Epidermophyton. |
|
Brand name |
Lamisil |
| Formulation and Efficacy: | Terbinafine HCl is available as a white crystalline powder that is soluble in various solvents such as methanol, ethanol, and dichloromethane. It exhibits lipophilic and keratinophilic properties, making it effective in penetrating the nail plate and reaching the site of infection. |
InChI:InChI=1/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+
78628-80-5 Relevant articles
Preparation method of terbinafine hydrochloride
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Paragraph 0041; 0044-0048; 0051-0055; 0058-0062; 0065-0068, (2020/09/12)
The invention provides a preparation met...
A PROCESS FOR THE PURIFICATION OF 1-HALO-6,6-DIMETHYL-HEPT-2-ENE-4-YNE
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Page/Page column 7, (2008/06/13)
The invention relates to a process for p...
Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels
Murat Şen, Cengiz Uzun, Olgun Güven
International Journal of Pharmaceutics Volume 203, Issues 1–2, 1 August 2000, Pages 149-157
Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH sensitive poly(acrylamide/maleic acid) (P(AAm/MA)) hydrogels were investigated. P(AAm/MA) hydrogels were prepared by irradiating the ternary mixtures of AAm/MA/and water by γ-rays at ambient temperature.
78628-80-5 Process route
-
- 14489-75-9
N-methyl-1-naphthalenemethylamine
-
- 287471-30-1
1-chloro-6,6-dimethyl-hept-2-ene-4-yn
-
- 78628-80-5,176168-78-8
terbinafine hydrochloride
| Conditions | Yield |
|---|---|
|
N-methyl-1-naphthalenemethylamine; 1-chloro-6,6-dimethyl-hept-2-ene-4-yn; With potassium carbonate; In water; at 80 ℃; for 4h; Large scale;
With hydrogenchloride; In water; at 0 - 10 ℃; Large scale;
|
93% |
-
- 14489-75-9
N-methyl-1-naphthalenemethylamine
-
- 78629-20-6
3-hydroxy-6,6-dimethylhept-1-ene-4-yne
-
- 78628-80-5,176168-78-8
terbinafine hydrochloride
| Conditions | Yield |
|---|---|
|
3-hydroxy-6,6-dimethylhept-1-ene-4-yne; With hydrogenchloride; trichlorophosphate; In methanol; at 0 - 20 ℃; for 20 - 24h;
N-methyl-1-naphthalenemethylamine; With sodium hydroxide; at 80 ℃;
With hydrogenchloride; In dichloromethane; water; at 20 ℃;
|
81% |
78628-80-5 Upstream products
-
91161-71-6
terbinafin
-
65473-13-4
N-methyl-1-naphthalenemethylamine hydrochloride
-
635708-74-6
(Z)-1-chloro-6,6-dimethylhept-2-en-4-yne
-
287471-30-1
1-chloro-6,6-dimethyl-hept-2-ene-4-yn
78628-80-5 Downstream products
-
91161-71-6
terbinafin
-
78628-81-6
(Z)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine
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