What is the 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-?

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- is White solid, while it's Molecular Formula is C22H19N3O6. White solid Rivaroxaban intermediate.

What is the CAS number for 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-?

The CAS number of 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- is 446292-08-6.

What is the 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-?

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- is White solid, while it's Molecular Formula is C22H19N3O6. White solid Rivaroxaban intermediate.

What is the CAS number for 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-?

The CAS number of 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- is 446292-08-6.

Product Class

446292-08-6

Product Name：Rivaroxaban intermediate
Molecular Formula：C₂₂H₁₉N₃O₆
Purity：99%
Molecular Weight：421.409

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Product Details:

CasNo： 446292-08-6

Molecular Formula： C₂₂H₁₉N₃O₆

Appearance： White solid

Chinese Factory Supply Reliable Quality Rivaroxaban intermediate 446292-08-6 Lowest Price

Molecular Formula:C22H19N3O6
Molecular Weight:421.409
Appearance/Colour:White solid
Vapor Pressure:0mmHg at 25°C
Melting Point:250
Refractive Index:1.658
Boiling Point:702.933 °C at 760 mmHg
PKA:0.99±0.20(Predicted)
Flash Point:378.92 °C
PSA：96.46000
Density:1.466 g/cm³
LogP:1.73910

Rivaroxaban intermediate (Cas 446292-08-6) Usage

Description	Rivaroxaban advanced intermediates are a class of drugs used to treat and prevent blood clots. Rivaroxaban is also known as Xarelto and is used as an oral anticoagulant in many medical formulations.
Uses	1H-isoindole-1,3(2H)-dione, 2-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]- is an important intermediate for the synthesis of rivaroxaban, which is an anticoagulant and the first orally active direct factor Xa inhibitor.
Chemical Properties	White Solid
Flammability and Explosibility	Nonflammable

InChI:InChI=1/C22H19N3O6/c26-19-13-30-10-9-23(19)14-5-7-15(8-6-14)24-11-16(31-22(24)29)12-25-20(27)17-3-1-2-4-18(17)21(25)28/h1-8,16H,9-13H2/t16-/m1/s1

446292-08-6 Relevant articles

A review on the synthetic approaches of rivaroxaban: An anticoagulant drug

Tanzeela Abdul Fattah, Aamer Saeed

Tetrahedron: Asymmetry Volume 28, Issue 4, 15 April 2017, Pages 485-504

This review comprehensively provides an overview of the various asymmetric synthetic methods employed for the synthesis of rivaroxaban in high yields and stereoselectivity describing the various chiral synthons used in the synthetic process along with pros and cons of each method. In addition, methods for the industrial production of rivaroxaban have been highlighted in the manuscript.

Clinical Pharmacokinetic and Pharmacodynamic Profile of Rivaroxaban

Wolfgang Mueck, Jan Stampfuss, Dagmar Kubitza & Michael Becka

,Clinical Pharmacokinetics, Volume 53, pages 1–16, (2014)

Variability in the pharmacokinetic parameters is moderate (coefficient of variation 30–40 %). The pharmacokinetic profile of rivaroxaban is consistent in healthy subjects and across a broad range of different patient populations studied.

446292-08-6 Process route

: 1325210-64-7
4-(4-isocyanatophenyl)morpholin-3-one

: 161596-47-0
(S)-N-glycidylphthalimide

: 446292-08-6,1424944-35-3
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With 3-methyl-1-butyl acetate; magnesium chloride; at 120 ℃; for 4h; Solvent; Reagent/catalyst; Temperature;	95.5%
With lithium iodide; In chlorobenzene; at 115 ℃; for 4h; Reagent/catalyst; Solvent; Temperature;	94.09%

: 634905-12-7
4-(4-bromophenyl)morpholin-3-one

: (S)-2-[[2-oxo-1,3-oxazolidin-5-yl]methyl]-1H-isoindole-1,3(2H)-dione

: 446292-08-6,1424944-35-3
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With copper(l) iodide; N,N-dimethyl-ethanamine; potassium carbonate; In dichloromethane; at 100 ℃; for 15h; Solvent; Reagent/catalyst; Sealed tube;	92.2%
With copper(l) iodide; N,N-dimethyl-ethanamine; potassium carbonate; In dichloromethane; at 100 ℃; for 15h; Sealed tube;	92.5%

446292-08-6 Upstream products

446292-07-5
2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
530-62-1
1,1'-carbonyldiimidazole
161596-47-0
(S)-N-glycidylphthalimide
438056-69-0
4-(4-aminophenyl)morpholin-3-one