32780-64-6
- Product Name：Labetalol hydrochloride
- Molecular Formula：C19H24N2O3.ClH
- Purity：99%
- Molecular Weight：364.872
Product Details:
CasNo： 32780-64-6
Molecular Formula： C19H24N2O3.ClH
Buy High Grade Labetalol hydrochloride ,Wholesale 32780-64-6 Efficient Shipping
- Molecular Formula:C19H24N2O3.ClH
- Molecular Weight:364.872
- Vapor Pressure:4.75E-13mmHg at 25°C
- Melting Point:187-189°
- Boiling Point:552.7 °C at 760 mmHg
- Flash Point:288.1 °C
- PSA：95.58000
- LogP:4.02860
Labetalol hydrochloride(Cas 32780-64-6) Usage
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Description |
Labetalol hydrochloride is a non-selective alpha1- and beta-adrenergic receptor blocking agent, commonly known as a beta blocker. It competitively targets alpha1-adrenergic receptors in vascular smooth muscle, inhibiting adrenergic stimulation and vasoconstriction. Additionally, it blocks beta-adrenergic receptors in bronchial and vascular smooth muscle, counteracting adrenergic stimulation. |
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Originator |
Trandate,Allen and Hanburys,UK,1977 |
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Uses |
Labetalol hydrochloride is used alone or in combination with other medications to treat high blood pressure (hypertension). High blood pressure increases the workload of the heart and arteries and, if left untreated, may lead to cardiovascular complications such as heart disease, heart attacks, and strokes. Labetalol helps to lower blood pressure, reducing the strain on the heart and arteries and preventing associated complications. Additionally, it can be used to prevent chest pain caused by angina. |
InChI:InChI=1/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H
32780-64-6 Relevant articles
Spectrophotometric methods for the determination of labetalol hydrochloride in pure and dosage forms
Chilukuri S. P. Sastry & Duppalapudi Murali Krishna
Microchimica Acta, Volume 122, pages 87–93, (1996)
Simple and sensitive Spectrophotometric methods for the determination of labetalol hydrochloride are described. The first two are based on the oxidative coupling reaction of labetalol hydrochloride withp-N,N-dimethyl-phenylenediamine dihydrochloride (method A, λmax 685 nm) and 3-methyl-2-benzothiazolinone hydrazone hydrochloride (method B, λmax 545 nm) in the presence of sodium hypochlorite and eerie ammonium sulphate as oxidants, respectively.
Arylethanolamines derived from salicylamide with α- and β-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers, and related salicylamides
Clifton,Collins,Hallett,Hartley,Lunts,Wicks
, p. 670 - 679 (2007/10/02)
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Formulation and evaluation of a gastroretentive dosage form of labetalol hydrochloride
Harshal Garse, Mohit Vij, Manohar Yamgar, Vilasrao Kadam & Rajashree Hirlekar
, Archives of Pharmacal Research, Volume 33, pages 405–410, (2010)
In the present work non-effervescent sustained release gastroretentive floating tablets of labetalol hydrochloride have been developed using various grades of HPMC and Poloxamer M127 as wetting agent.
32780-64-6 Process route
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- 32780-63-5
2-hydroxy-5-<
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- 32780-64-6
labetalol hydrochloride
| Conditions | Yield |
|---|---|
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With hydrogen; platinum on activated charcoal; palladium oxide on charcoal; In ethanol; under 760 Torr; Ambient temperature;
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67% |
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- 85665-85-6
C19H22N2O3
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- 32780-64-6
labetalol hydrochloride
| Conditions | Yield |
|---|---|
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C19H22N2O3; With water; sodium hydroxide; In methanol; at 1 - 20 ℃; for 0.5h;
With sodium tetrahydroborate; water; In methanol; at 15 - 25 ℃;
With hydrogenchloride; In methanol; water; at 20 ℃; for 2h; pH=2;
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32780-64-6 Upstream products
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32780-63-5
2-hydroxy-5-<
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2550-26-7
4-Phenyl-2-butanone
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30566-92-8
5-(N,N-dibenzylamino)acetylsalicylamide
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85665-85-6
C19H22N2O3
32780-64-6 Downstream products
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32551-03-4
(R,S)-2-hydroxy-5-<2-<(1-methyl-3-phenylpropyl)amino>ethyl>benzamide hydrochloride
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22374-89-6
(RS)-1-methyl-3-phenylpropylamine
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76143-20-9
5-formyl-2-hydroxy-benzamide
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