What is the Irinotecan hydrochloride?

Irinotecan hydrochloride is Yellow crystalline powder, while it's Molecular Formula is C33H38N4O6 . HCl. Yellow crystalline powder A DNA topoisomerase inhibitor

What is the CAS number for Irinotecan hydrochloride?

The CAS number of Irinotecan hydrochloride is 100286-90-6.

What is Irinotecan hydrochloride (100286-90-6) used for?

lrinotecan hydrochloride, a semi-synthetic, water soluble derivative of the potentanticancer agent camptothecin, was launched in Japan for the treatment of lung,ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibitionof topoisomerase I, a cellular enzyme that is involved in maintaining the topographicstructure of DNA during the process of translation, transcription, and mitosis.lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38,which is 1000-fold more potent than the parent. Although being much less toxic thancamptothecin, a significant number of patients in clinical trials exhibited side effectsof leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy ofirinotecan with another widely used anticancer agent, cisplatin, has been reported tobe superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal,breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin'slymphoma.InChI:InChI=1/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1

Product Class

100286-90-6

Product Name：Irinotecan Hcl
Molecular Formula：C₃₃H₃₈N₄O₆^.HCl
Purity：99%
Molecular Weight：623.149

Inquiry

Product Details:

CasNo： 100286-90-6

Molecular Formula： C₃₃H₃₈N₄O₆^.HCl

Appearance： Yellow crystalline powder

Buy Quality Irinotecan Hcl,Sale 100286-90-6 Safe Transportation

Molecular Formula:C33H38N4O6^.HCl
Molecular Weight:623.149
Appearance/Colour:Yellow crystalline powder
Vapor Pressure:1.31E-32mmHg at 25°C
Melting Point:250-256 ºC (dec.)
Refractive Index:67.7 ° (C=1, H2O)
Boiling Point:873.4 ºC at 760 mmHg
Flash Point:482 ºC
PSA：114.20000
LogP:4.76890

Irinotecan Hcl(Cas 100286-90-6) Usage

Description	Irinotecan hydrochloride, also known as CPT-11, is a chemotherapy drug categorized as a topoisomerase I inhibitor. It is a water-soluble semisynthetic derivative of camptothecin, functioning as an inhibitor of Topoisomerase I.
Chemical Properties	Yellow Crystalline Powder
Originator	Yakult Honsha (Japan)
Uses	Irinotecan hydrochloride is primarily used in the treatment of cancer of the colon and rectum. It may be administered alone or in combination with other chemotherapy medications. Irinotecan is typically used as part of a comprehensive treatment regimen for colon or rectal cancer, often in combination with other chemotherapy drugs or radiation therapy. The specific treatment plan may vary depending on factors such as the stage and severity of the cancer, as well as individual patient characteristics.
Brand name	Camptosar (Pharmacia &Upjohn) ;Topotecin.
Therapeutic Function	Antineoplastic

InChI:InChI=1/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1

100286-90-6 Relevant articles

Irinotecan hydrochloride is a pale yellow to yellow crystalline powder

Kumar V Kiran1, Raju N Appala2,*, Rani Namratha2, Rao JVLN Seshagiri3, Satyanarayana T2

, Asian Journal of Research in Chemistry, 2009, Volume : 2, Issue : 1

The percentage assay of Irinotecan HCl was 99.09%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Irinotecan HCl in bulk drug and in its pharmaceutical dosage form.

Cell Cycle-Dependent Chronotoxicity of Irinotecan Hydrochloride in Mice

Shigehiro Ohdo, Tomoko Makinosumi, Takashi Ishizaki, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano and Nobuya Ogawa

Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1383-1388;

The mechanisms underlying the circadian rhythm of the toxicity induced by irinotecan hydrochloride (CPT-11; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) were investigated from the viewpoint of the sensitivity of living organisms and the pharmacokinetics of the drug.

100286-90-6 Process route

: irinotecan carboxylate

: 100286-90-6
irinotecan hydrochloirde

Conditions

Conditions	Yield
With Britton-Robinson's buffer pH 6.0; water; at 37 ℃; Equilibrium constant; Kinetics; Thermodynamic data; E_a, A, var. pH, var. temp., var. time;

: 97682-44-5,130144-33-1
irinotecan

: 100286-90-6
irinotecan hydrochloirde