What is the Gemfibrozil?

Gemfibrozil is White crystalline powder, while it's Molecular Formula is C15H22O3. White crystalline powder Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.

What is the CAS number for Gemfibrozil?

The CAS number of Gemfibrozil is 25812-30-0.

What is Gemfibrozil (25812-30-0) used for?

Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.InChI:InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

What is the Gemfibrozil?

Gemfibrozil is White crystalline powder, while it's Molecular Formula is C15H22O3. White crystalline powder Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.

What is the CAS number for Gemfibrozil?

The CAS number of Gemfibrozil is 25812-30-0.

What is Gemfibrozil (25812-30-0) used for?

Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.InChI:InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

Product Class

25812-30-0

Product Name：Gemfibrozil
Molecular Formula：C₁₅H₂₂O₃
Purity：99%
Molecular Weight：250.338

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Product Details:

CasNo： 25812-30-0

Molecular Formula： C₁₅H₂₂O₃

Appearance： White crystalline powder

Buy Best Quality Gemfibrozil 25812-30-0 In Bulk Supply

Molecular Formula:C15H22O3
Molecular Weight:250.338
Appearance/Colour:White crystalline powder
Vapor Pressure:6.13E-07mmHg at 25°C
Melting Point:61-63 °C
Refractive Index:1.511
Boiling Point:394.7 °C at 760 mmHg
PKA:4.75±0.45(Predicted)
Flash Point:141.6 °C
PSA：46.53000
Density:1.044 g/cm³
LogP:3.57320

Gemfibrozil(Cas 25812-30-0) Usage

Description	Gemfibrozil is a lipid-regulating agent belonging to the group of phenoxy aromatic acid antihyperlipidemics. It acts as a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist, exerting its therapeutic effects by reducing serum total cholesterol, triglycerides, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) levels. It is primarily indicated for the management of dyslipidemia and the prevention of coronary heart disease in high-risk patients.
Chemical properties	Crystallized from hexane, melting point of 61-63℃, and boiling point of 158-159℃ (2.67 Pa). Acute toxicity test: the LD50 values in mice and rats given orally were 3162 and 4786 mg/kg respectively.
Uses	Gemfibrozil is highly effective in reducing serum triglyceride levels, particularly in patients with very high triglyceride levels (hypertriglyceridemia). By lowering lipid levels, it helps reduce the risk of atherosclerosis and related cardiovascular events. Gemfibrozil exerts significant effects on lipid profiles, leading to reductions in serum total cholesterol, LDL cholesterol, and VLDL cholesterol levels, while increasing high-density lipoprotein (HDL) cholesterol levels.
Originator	Lopid,Warner Lambert,US,1982
Brand name	Lopid (Pfizer);Gevilon;Hipolixan;Ipolipid;Lipur;Tenorac.
Therapeutic Function	Antihyperlipidemic

InChI:InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

25812-30-0 Relevant articles

Aryloxycyclohexyl amide AMPK agonist as well as preparation method and medical application thereof

-

, (2022/04/06)

The invention discloses an aryloxy cyclo...

Mechanism of action of gemfibrozil on lipoprotein metabolism.

K Saku, P S Gartside, B A Hynd, and M L Kashyap

The Journal of Clinical Investigation, 1985

Each patient was admitted to the Clinical Research Center with metabolic kitchen facilities, for investigation of HDL and TG metabolism immediately before and after 8 wk of gemfibrozil treatment. Gemfibrozil significantly increased plasma HDL cholesterol, apolipoprotein (apo) AI, and apo AII by 36%, 29%, and 38% from base line, respectively. Plasma TG decreased by 54%.

Gemfibrozil greatly increases plasma concentrations of cerivastatin

Janne T. Backman MD, Carl Kyrklund MB, Mikko Neuvonen MSc, Pertti J. Neuvonen MD

Clinical Pharmacology & Therapeutics, Volume72, Issue6 December 2002 Pages 685-691

In a randomized, double-blind crossover study, 10 healthy volunteers took 600 mg gemfibrozil or placebo twice daily for 3 days. On day 3, each subject ingested a single 0.3-mg dose of cerivastatin. Plasma concentrations of cerivastatin, its metabolites, and gemfibrozil were measured up to 24 hours.

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