95734-82-0

Product Details:

CasNo： 95734-82-0

Molecular Formula： C2H6N2O3Pt

Appearance： Light yellow to yellow powder

Delivery Time： 2 weeks after order

Throughput： 100KG/Month

Purity： 99%

Synonyms: (glycolato-o,o')diammineplatinum(ii); cis-diammine(glycolato)platinum(ii); 254-s; Aqupla; cis-diamine-glycolate-O,O'-platinum(II); o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu
Solubility: H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity) DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
Boiling point: 265.6ºC at 760 mmHg
Flash point: 128.7ºC

Description:
Nedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.

Uses:

Nedaplatin is a platinum complex that has potent antineoplatic activity.
Anticancer.