1075705-01-9
- Product Name：4-Fluoro-2-methoxy-5-nitroaniline
- Molecular Formula：C7H7FN2O3
- Purity：99%
- Molecular Weight：186.143
Product Details:
CasNo： 1075705-01-9
Molecular Formula： C7H7FN2O3
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- Molecular Formula:C7H7FN2O3
- Molecular Weight:186.143
- Melting Point:130 °C
- Boiling Point:354.8±37.0 °C(Predicted)
- PKA:2.31±0.10(Predicted)
- PSA：81.07000
- Density:1.412±0.06 g/cm3(Predicted)
- LogP:2.42910
4-Fluoro-2-methoxy-5-nitroaniline(Cas 1075705-01-9) Usage
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Description |
4-Fluoro-2-methoxy-5-nitroaniline exists as a solid compound under normal conditions. |
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Uses |
4-Fluoro-2-methoxy-5-nitroaniline is a chemical compound utilized as a reagent in the synthesis of the anticancer drug Mereletinib. It plays a crucial role in the preparation of Mereletinib, a potent inhibitor of mutant BRAFV600E kinase, which shows promise in the treatment of various types of cancers. |
| Process for Preparation | 4-Fluoro-2-methoxy-5-nitroaniline can be synthesized through a multi-step process involving protection, nitration, and deprotection of 4-fluoro-2-methoxyaniline, leading to the formation of 4-fluoro-2-methoxy-5-nitroaniline or its salts. |
1075705-01-9 Relevant articles
Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib
Manuel Köckinger, Benjamin Wyler, Christof Aellig, Dominique M. Roberge, Christopher A. Hone*, and C. Oliver Kappe*
, Org. Process Res. Dev. 2020, 24, 10, 2217–2227
The development of a scalable telescoped continuous flow procedure for the acetylation and nitration of 4-fluoro-2-methoxyaniline is described. A subsequent batch deprotection then affords 4-fluoro-2-methoxy-5-nitroaniline, a key building block in the synthesis of osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that is used for the treatment of nonsmall-cell lung carcinomas carrying EGFR-TKI sensitizing and EGFR T790M resistance mutations.
Improvements in the Synthesis of the Third-Generation EGFR Inhibitor Osimertinib
Pinelopi Voulgari, Dimitrios Alivertis, Konstantinos Skobridis
, Helvetica Chimica Acta, Volume104, Issue11 November 2021 e2100066
… the hydrochloride salt of 4-fluoro-2-methoxy-5-nitroaniline (6) … commercially available 4-fluoro-2-methoxy-5-nitroaniline (6) … dried to give quantitatively 4-fluoro-2-methoxy-5-nitroaniline …
Compound for inhibiting three-mutant epidermal growth factor receptor tyrosine kinase and application thereof
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Paragraph 0039; 0073; 0074; 0078-0080, (2021/09/15)
A core building block in the synthesis of 1 is a tetrasubstituted benzene ring that is derived from 4-fluoro-2-methoxy-5-nitroaniline (2) (Scheme 1). Compound 2 can be prepared by the …
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