What is the sodium,8-[(2-hydroxybenzoyl)amino]octanoate?

sodium,8-[(2-hydroxybenzoyl)amino]octanoate is , while it's Molecular Formula is C15H20NNaO4. Salcaprozate Sodium is a drug excipient or inactive ingredient in drug formulations.

What is the CAS number for sodium,8-[(2-hydroxybenzoyl)amino]octanoate?

The CAS number of sodium,8-[(2-hydroxybenzoyl)amino]octanoate is 203787-91-1.

What is sodium,8-[(2-hydroxybenzoyl)amino]octanoate (203787-91-1) used for?

Salcaprozate sodium (SNAC) is the sodium salt form of salcaprozate, an oral absorption promoter. Salcaprozate sodium may be used as a delivery agent to promote the oral absorption of certain macromolecules with poor bioavailability such as insulin and heparin.It is also used as an excipient in drug formulation as a chemical permeation enhancer (PE) to aid the oral absorption of macromolecules, peptides and proteins such as insulin (diabetes), heparin (heart attacks and angina) and cyanocobalamin (vitamin B12 deficiency and anaemia) which would otherwise have poor bioavailability. SNAC is considered to be safe for human consumption (GRAS) by the FDA.InChI:InChI=1/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1

What is the sodium,8-[(2-hydroxybenzoyl)amino]octanoate?

sodium,8-[(2-hydroxybenzoyl)amino]octanoate is , while it's Molecular Formula is C15H20NNaO4. Salcaprozate Sodium is a drug excipient or inactive ingredient in drug formulations.

What is the CAS number for sodium,8-[(2-hydroxybenzoyl)amino]octanoate?

The CAS number of sodium,8-[(2-hydroxybenzoyl)amino]octanoate is 203787-91-1.

What is sodium,8-[(2-hydroxybenzoyl)amino]octanoate (203787-91-1) used for?

Salcaprozate sodium (SNAC) is the sodium salt form of salcaprozate, an oral absorption promoter. Salcaprozate sodium may be used as a delivery agent to promote the oral absorption of certain macromolecules with poor bioavailability such as insulin and heparin.It is also used as an excipient in drug formulation as a chemical permeation enhancer (PE) to aid the oral absorption of macromolecules, peptides and proteins such as insulin (diabetes), heparin (heart attacks and angina) and cyanocobalamin (vitamin B12 deficiency and anaemia) which would otherwise have poor bioavailability. SNAC is considered to be safe for human consumption (GRAS) by the FDA.InChI:InChI=1/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1

Product Class

203787-91-1

Product Name：Salcaprozate Sodium
Molecular Formula：C₁₅H₂₀NNaO₄
Purity：99%
Molecular Weight：301.3134

Inquiry

Product Details:

CasNo： 203787-91-1

Molecular Formula： C₁₅H₂₀NNaO₄

Factory Supply High Purity Salcaprozate Sodium 203787-91-1 Safe Transportation

Molecular Formula:C15H20NNaO4
Molecular Weight:301.3134
Vapor Pressure:1.03E-11mmHg at 25°C
Melting Point:183 - 185°C
Boiling Point:521.7°Cat760mmHg
Flash Point:269.3°C
PSA：89.46000
Density:g/cm³
LogP:1.60340

Salcaprozate Sodium(Cas 203787-91-1) Usage

Description

Salcaprozate sodium (SNAC) is the sodium salt form of salcaprozate, serving as an oral absorption promoter. It acts as a chemical permeation enhancer (PE) and is commonly utilized as a delivery agent to enhance the oral absorption of macromolecules, particularly those with poor bioavailability, such as insulin and heparin. In drug formulation, SNAC is employed as an excipient to aid the oral absorption of various macromolecules, peptides, and proteins, including insulin for diabetes, heparin for heart attacks and angina, and cyanocobalamin for vitamin B12 deficiency and anemia.

Uses

Salcaprozate sodium is considered safe for human consumption and has obtained Generally Recognized as Safe (GRAS) status from the FDA. It is known to be one of the most advanced chemical permeation enhancers, alongside sodium caprate (C10), and both are generally acknowledged as safe and efficacious for use in marketed drug products. Salcaprozate sodium, also referred to by its chemical name sodium 8-(2-hydroxybenzamido)octanoate, is supplied as a hygroscopic white to off-white solid by Actylis.

InChI:InChI=1/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1

203787-91-1 Relevant articles

Subchronic Oral Toxicity of Salcaprozate Sodium (SNAC) in Sprague-Dawley and Wistar Rats

M. Gary I. Riley griley@emisphere.com, M. Cristina Castelli, and Ellen Angela Paehler

International Journal of Toxicology, Volume 28, Issue 4

The present report summarizes the findings of 2 separate studies that explored the subchronic oral toxicity of SNAC in Sprague-Dawley and Wistar rats. The first study, sponsored by Emisphere Technologies, Inc (Cedar Knolls, New Jersey), employed SNAC alone and in combination with heparin.

A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10)

Caroline Twarog a b, Kai Liu b c, Peter J. O'Brien a, Kenneth A. Dawson b c, Elias Fattal d, Brigitte Illel e, David J. Brayden a b

European Journal of Pharmaceutics and Biopharmaceutics Volume 152, July 2020, Pages 95-107

The MCFA, sodium caprate (C10), and the C8 derivative, salcaprozate sodium (SNAC), are the key components of the most advanced solid-dose oral peptide formulations with over 20 year’s experience in clinical trials. SNAC (Emisphere, NJ, USA) has been assessed in multiple Phase III PIONEER trials in tablets with the Glucagon-like-1 peptide analogue, semaglutide..

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