What is the Valbenazine?

Valbenazine is , while it's Molecular Formula is C24H38N2O4. Valbenzine is a highly selective vesicular monoamine transporter 2 inhibitor. It is used in the treatment of tardive dykinesia.

What is the CAS number for Valbenazine?

The CAS number of Valbenazine is 1025504-45-3.

What is the Valbenazine?

Valbenazine is , while it's Molecular Formula is C24H38N2O4. Valbenzine is a highly selective vesicular monoamine transporter 2 inhibitor. It is used in the treatment of tardive dykinesia.

What is the CAS number for Valbenazine?

The CAS number of Valbenazine is 1025504-45-3.

Product Class

1025504-45-3

Product Name：Valbenazine base
Molecular Formula：C24H38N2O4
Purity：99%
Molecular Weight：418.577

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Product Details:

CasNo： 1025504-45-3

Molecular Formula： C24H38N2O4

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Molecular Formula:C24H38N2O4
Molecular Weight:418.577
Boiling Point:507.2±50.0 °C(Predicted)
PKA:7.76±0.33(Predicted)
PSA：74.02000
Density:1.11±0.1 g/cm3(Predicted)
LogP:4.20230

Valbenazine base(Cas 1025504-45-3) Usage

Description

Valbenazine is a medication designed to address tardive dyskinesia, a drug-induced neurological injury characterized by involuntary and repetitive movements. Its chemical name is (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-3,4,6,7,11b-5H-benzo[a]quinolizine. As a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, valbenazine reduces the uptake of dopamine into vesicles within nerve cells.

Uses

Clinical trials leading to the approval of valbenazine by the US Food and Drug Administration (FDA) were six weeks in duration. An industry-sponsored study extended the evaluation to 48 weeks, demonstrating the medication's safety and effectiveness in maintaining short-term (6-week) improvements in tardive dyskinesia. Valbenazine, often available in salt forms like the hydrochloride salt, is prescribed under the supervision of healthcare professionals. It serves to alleviate the severity of abnormal movements associated with tardive dyskinesia in adults. As with any medication, adherence to proper dosage and monitoring for potential side effects are essential, warranting guidance from healthcare providers to ensure safe and effective

1025504-45-3 Relevant articles

Crystalline forms of valbenazine ditosylate

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Page/Page column 9-10, (2020/07/09)

Disclosed herein are new crystalline for...

CRYSTALLINE VALBENAZINE FREE BASE

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Page/Page column 19, (2018/08/03)

The present disclosure generally relates...

SUBSTITUTED 3-ISOBUTYL-9, 10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A] ISOQUINOLIN-2-OL COMPOUNDS AND METHODS RELATING THERETO

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Page/Page column 14-15, (2008/12/05)

Substituted 3-isobutyl-9,10-dimethoxy-1,...

1025504-45-3 Process route

: 1025504-76-0
(S)-2-benzyloxycarbonyl-amino-3-methylbutyric acid-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester

: 1025504-45-3
(S)-2-amino-3-methylbutyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolizin-2-yl ester

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; In methanol;	85%
With palladium on activated charcoal; hydrogen; In methanol; Inert atmosphere;	59 g

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: (2R,3R,11bR)-dihydrotetrabenazine

: 1025504-45-3
(S)-2-amino-3-methylbutyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolizin-2-yl ester

Conditions

Conditions	Yield
(S)-N-(benzyloxycarbonyl)valine; (2R,3R,11bR)-dihydrotetrabenazine; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h; With palladium on activated charcoal; hydrogen; In methanol; for 2h;