What is the 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-?

2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)- is , while it's Molecular Formula is C19H27NO3. (3R,11bR)-Tetrabenazine is an isomer of Tetrabenazine (T284000), a dopamine depleting agent, an antidyskinetic and antipsychotic.

What is the CAS number for 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-?

The CAS number of 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)- is 1026016-83-0.

What is the 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-?

2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)- is , while it's Molecular Formula is C19H27NO3. (3R,11bR)-Tetrabenazine is an isomer of Tetrabenazine (T284000), a dopamine depleting agent, an antidyskinetic and antipsychotic.

What is the CAS number for 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-?

The CAS number of 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)- is 1026016-83-0.

Product Class

1026016-83-0

Product Name：Valbenazine ditosylate intermediate-02
Molecular Formula：C₁₉H₂₇NO₃
Purity：99%
Molecular Weight：317.42

Inquiry

Product Details:

CasNo： 1026016-83-0

Molecular Formula： C₁₉H₂₇NO₃

Quality Manufacturer Supply High Purity Valbenazine ditosylate intermediate-02 1026016-83-0 Competitive Price

Molecular Formula:C19H27NO3
Molecular Weight:317.42
Melting Point:108-110 °C
Boiling Point:448.9 °C at 760 mmHg
PKA:6.46±0.40(Predicted)
Flash Point:225.3 °C
PSA：38.77000
Density:1.12g/cm³
LogP:3.17600

Valbenazine ditosylate intermediate-02(Cas 1026016-83-0) Usage

Description	Valbenazine ditosylate intermediate-02 is an intermediate compound in the synthesis of valbenazine ditosylate, which is the active pharmaceutical ingredient (API) in the medication Ingrezza used to treat tardive dyskinesia and chorea associated with Huntington's disease.
Uses	Valbenazine ditosylate intermediate-02 plays a crucial role in the synthetic pathway to produce valbenazine ditosylate. During the manufacturing process, various intermediates are synthesized, each step carefully designed to achieve the desired chemical structure of the final API.

1026016-83-0 Relevant articles

A concise total synthesis of (+)-tetrabenazine and (+)-α- dihydrotetrabenazine

Paek, Seung-Mann,Kim, Nam-Jung,Shin, Dongyun,Jung, Jae-Kyung,Jung, Jong-Wha,Chang, Dong-Jo,Moon, Hyunyoung,Suh, Young-Ger

, p. 4623 - 4628 (2010)

Highly concise asymmetric total synthese...

Asymmetric synthesis of tetrabenazine and dihydrotetrabenazine

Rishel, Michael J.,Amarasinghe, Kande K. D.,Dinn, Sean R.,Johnson, Bruce F.

, p. 4001 - 4004 (2009)

(Chemical Equation Presented) The enanti...

Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors

Yao, Zhangyu,Wei, Xueying,Wu, Xiaoming,Katz, Jonathan L.,Kopajtic, Theresa,Greig, Nigel H.,Sun, Hongbin

, p. 1841 - 1848 (2011)

Tetrabenazine (TBZ) ((±)-1) and dihydrot...

Preparation method of benzoquinolizine derivative

-

, (2020/07/06)

The invention relates to a preparation m...

Dynamic resolution method of tetrabenazine

-

Paragraph 0036-0054, (2019/10/01)

The invention provides a dynamic resolut...

SOLID STATE FORMS OF VALBENAZINE

-

, (2018/04/21)

Solid state forms of Valbenazine, Valben...

CRYSTALLINE VALBENAZINE FREE BASE

-

Page/Page column 18, (2018/08/03)

The present disclosure generally relates...

1026016-83-0 Process route

: 1091627-89-2
(R)-tert-butyl 6,7-dimethoxy-1-(5-methyl-3-methylene-2-oxohexyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1026016-83-0,1381929-92-5
((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one)

Conditions

Conditions	Yield
With dimethylsulfide; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;	46%
With dimethylsulfide; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;	46%
(R)-tert-butyl 6,7-dimethoxy-1-(5-methyl-3-methylene-2-oxohexyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate; With dimethylsulfide; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; With potassium carbonate; In dichloromethane; water; at 0 ℃;	46%
With dimethylsulfide; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;	46%
(R)-tert-butyl 6,7-dimethoxy-1-(5-methyl-3-methylene-2-oxohexyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate; With dimethylsulfide; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; With potassium carbonate; In dichloromethane; water; at 0 ℃;	46%

: (3R,11bR)-3-isobutyl-9,10-dimethoxy-2-oxo-1,2,3,4,5,6,7,11b-octahydropyrido[2,1-a]isoquinolin-5-ium (2S,3S)-3-carboxy-2,3-bis((4-methylbenzoyl)oxy)propanoate